![]() however, HPR did not achieve gene transcription levels of ATRA (tretinoin)." But, a much higher dose might be tolerated from HPR and the highest dose of HPR out-performed tretinoin. The results are pretty encouraging showing that " HPR had greater levels of gene transcription than retinol and RP (RP) at the same concentrations. Regarding anti-aging, there is a pretty recent, Estee Lauder sponsored study that compared the in-vitro (not on real human beings but on skin models) collagen-boosting effectiveness of Hydroxypinacolone Retinoate, tretinoin, good old retinol and retinyl palmitate (RP). Both studies found the formulas effective but they contained other things too, so it's hard to judge how well HPR did. We found two Italian studies both examining the efficacy of HPR combined with other things (retinol in both cases, and papain in one of them) for the treatment of acne. But, before you do, you have to know that the info we have about HPR at the moment is mainly from the manufacturer, whose tests may or may not be accurate or properly designed (such as controlled, double-blind and conducted on an appropriate number of people).Īs HPR is pretty new there isn't that much independent research we could find yet. These results sound sooo promising that we don't blame you if you wanna run out right now and get an HPR formula to slather on your face. Also, there was a "dramatic reduction of lines and wrinkles" after applying 0.2% HPR around the eyes twice a day for 14 days. According to the manufacturer's tests, 24 hours of an occlusive patch with 0.5% HPR resulted in significantly lower irritation than 0.5% retinol. The big promise of HPR is that it's similarly active as retinoic acid (no conversion needed, remember) but without the irritation. It binds directly to the retinoid receptors of the skin cells to work its skincare magic. Other forms of retinoids have to be converted by our metabolic machinery to do something. If you've already read our description about retinol or retinyl palmitate, you know that the active ingredient our skin cells can interpret is retinoic acid. It's a so-called retinoic acid ester, meaning that it's directly related to retinoic acid. ![]() If any redness, burning, itching, blistering or irritation is observed at any time throughout the test, do not use the product.Rosmarinus Officinalis (Rosemary) Leaf Extract.If the product has a specified duration of use, rinse off after this time has elapsed.Apply a small amount of the product onto a clean area of skin on the upper forearm.We have outlined a general method for conducting your own patch test below based on the type of product. It is recommended to perform a patch test before incorporating any new product into your regimen. Patch tests are an easy way to help predict if you may experience a negative initial reaction to a new product. Find out which celebrity swears by this product in our blog Celebrity Beauty Secrets.Check out our 3 Step Mini Guide to The Ordinary Products and discover all you need to know about this revolutionary brand!.We recommend wearing broad spectrum SPF sunscreen during the day. Retinoids can make your skin more sensitive to UV radiation. ![]()
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